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Serum tHcy levels were substantially correlated with the MTHFR C677T mutation, folate insufficiency, and B12 deficiency [48]
Additionally, genes implicated in the AMPK signaling pathway, including cystic fibrosis transmembrane conductance regulator ( Cftr ) and protein kinase AMP-activated non-catalytic subunit gamma 3 ( Prkag3 ), along with those associated with oxidative phosphorylation, such as cytochrome c oxidase subunit 6a2 ( Cox6a2 ) and ATPase H + transporting v1 subunit g3 ( Atp6v1g3 ), were significantly downregulated
doi: 10.1016/j.onano.2025.100243 [DOI] [Google Scholar] 79.Alam MI, Baboota S, Ahuja A, Ali M, Ali J, Sahni JK
LeeJJIshiharaKNotomiSEfstathiouNEUetaTMaidanaDet alLysosome-associated membrane protein-2 deficiency increases the risk of reactive oxygen species-induced ferroptosis in retinal pigment epithelial cells
pii: 20170230
These intrinsic defects align with the pathological features of MS and suggest an important role for macrophages
