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In addition, intact mitochondrial calcium homeostasis serves as an important protective barrier by confining potentially harmful mitochondrial contents, including cytochrome c, apoptosis-inducing factor (AIF), and mtDNA fragments, within the organelle and preventing their release into the cytosol, where they could trigger inflammation, necrosis, or abnormal apoptosis (see Figure 2)

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Increase in insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 1 after supplementation with selenium and coenzyme Q10

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