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Neuroendocrine dysfunction in gamma-aminobutyric acid (GABA) signaling and neuronal androgen receptors that might alter hypothalamic sensitivity and lead to an impairment of estradiol and progesterone feedback

Three patients exhibit a mild response (the number of crises decrease of 33% for two patients and of 50% for the other one

The undesirable effects associated with tricyclic antidepressants and monoamine oxidase inhibitors constrain their regular application in those with cirrhosis (34)