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Description
For decreases in renal function while receiving deferasirox [see Warnings and Precautions (5.1)], modify the dose as follows: Transfusional Iron Overload Adults: Pediatric Patients (ages 2 years to 17 years): Reduce the dose by 10 mg/kg/day if eGFR decreases by greater than 33% below the average baseline measurement and repeat the eGFR within 1 week

This internal "friction" directly impacts power delivery

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Besides, many supplement trials are plagued by the problem of inadequate differences between the treatment and controls groups with regard to vitamin C concentrations, addressed in detail above

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