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The pathways that appear active in those models do not automatically translate to predictable, beneficial effects in human patients

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Journal of Alzheimers Disease 2018;64, S3-S22

9.3 Replace relative intensity values lower than 500 by NA, log2 transform the data, and perform additional data normalization, if necessary, based on data quality inspection

Another meta-analysis, published in 2021, examined the results of six SGLT2 inhibitor trials that included nearly 47,000 subjects with type 2 diabetes, about 31,000 of whom had atherosclerotic cardiovascular disease