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Research suggests that arsenic trioxide, used in the treatment of acute promyelocytic leukemia, induces apoptosis and generates reactive oxygen species (ROS) as part of its mechanism of action (Murillo et al., 2022

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[DOI] [PMC free article] [PubMed] [Google Scholar] 114.Michelet L., Zaffagnini M., Massot V., Keryer E., Vanacker H., Miginiac-Maslow M., Issakidis-Bourguet E., Lemaire S.D
C2 domains of Munc13-4 are crucial for Ca(2+)-dependent degranulation and cytotoxicity in NK cells
