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Poor oral bioavailability is one of the greatest obstacles: curcumin is quickly eliminated in the liver and intestines to glucuronide and sulfate conjugates, which leads to low systemic exposure, short plasma half-life and low tissue penetration [12]

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L., Talley, N

2, MTHFR catalyzes the physiologically irreversible reduction of 5,10-methylene THF to 5-methyltetrahydrofolate (5-methyl THF), and plays a critical role in one-carbon metabolism for the reaction of producing methyl groups to participate in epigenetic regulation 18

[DOI] [PubMed] [Google Scholar] 111.Deigendesch N, Zychlinsky A, Meissner F

Rho-kinase, a serinethreonine kinase is known to cause endothelial dysfunction by inactivating eNOS and reducing NO generation (Nohria et al., 2006)