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In addition to its role in energy metabolism, creatine appears to act as a buffer against the harmful effects of reactive oxygen species in cardiovascular tissues, potentially slowing the progression of cardiovascular disease [110], although this is a topic that deserves further investigation as not all evidence shows benefits of higher intracellular levels of creatine [111]

Nature 468 , 10671073 (2010)

Its sources include, for example, meat, fish and dairy products

C., Emery, A.,

Once a bottle has been opened, even when it is stored in a fridge- we recommend that it is discarded within 4-weeks
Thiel, J