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There is no scientific consensus supporting immediate effects

In the course of COPD disease, pro-inflammatory cytokines, ROS, CRP may disrupt the regulation of TJs in brain endothelial cells, increasing BBB permeability, damaging brain cells, and promoting atherosclerosis in both the anterior and internal cerebral arteries[96, 150, 151]

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Acknowledgments This work was supported by grants from Agencia Nacional de Promocin Cientfica y Tecnolgica (PICT 2012-1753 and PICT 2014-0476) to Carolina I

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