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Sanders KM, Kotowicz MA, Nicholson GC
Aging and wound healing of the skin: A review of clinical and pathophysiological hallmarks

Am J Pathol 188:491506
Combining this information with the phenomena of particle aggregation of the gold nanoparticles in the presence of APTES, the following mechanism for the observed visual detection is proposed

21 Alternatively, predominant sicca symptoms in the setting of dysautonomia with or without sensory abnormalities may warrant testing for Sjgren syndrome A and B (SSA and SSB) antibodies

A shadow might be cast in the area where there is a hollow under the eye