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That finding alone makes it worth considering for anyone struggling with GI-related side effects

Anyone with significant medical conditions, anyone pregnant or breastfeeding, and anyone on multiple medications needs a careful review first not because problems are expected, but because limited human data means we don't assume

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Some supplements require refrigeration or another type of special storage

For reference, these are the Recommended Dietary Allowances (RDA) for vitamin B12 by sex and age group indicating the daily amount needed for healthy individuals ( Men 1418: 2.4 mcg Men 19+: 2.4 mcg Women 1418: 2.4 mcg Women 19+: 2.4 mcg During pregnancy: 2.4 mcg During lactation: 2.8 mcg SUMMARY The RDA for vitamin B12 for most people is 2.4 mcg per day

The best results appear around the eyes, mouth, forehead, and cheeks