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doi: 10.1038/nature11550 47 ParfreyLWKnightR

An R, Wu C, Tang C, Zhang C, Han F, Xu Z, et al

As we age, phosphatidylcholine levels decline and cholesterol becomes more dominant in the cell membrane, which can reduce cellular flexibility

When taken in pill form, it can be quickly broken down in the digestive tract before it reaches the cells, reducing its effectiveness
Notably, in Arabidopsis thaliana the mutation of arGST tt19 completely eliminates production of epicatechin 34 an unexpected outcome in the frame of the ligandin model as the cytosolic availability of cyanidin ( 8-AH + ), the precursor molecule of epicatechin ( 19 ), should be unaffected by mutating a transport protein
