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Estrogen has been shown to upregulate endogenous MOTS-c expression in preclinical models, which may partly explain why metabolic deterioration accelerates in perimenopause when estrogen falls precipitously [2]
2021;31(34) doi: 10.1002/adfm.202102794

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1 illustrates the essential reactions and feedback mechanisms among ROS, GSH, GSSG, NADPH and G6P in the outer retina, which we focus on and model as a system of ordinary differential equations (ODEs), where all parameters are non-negative
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