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Collectively, this blend provides a framework for examining interconnected pathways related to cytoprotection, angiogenic modulation, extracellular matrix regulation, and metal-mediated signaling processes

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M2 macrophages mainly secrete IL-10 and TGF-1 as well as the chemokines CCL17, CCL18 and CCL19 (2631, 35, 36)

Among these cells, tumor-associated macrophages (TMAs) are the most abundant tumor-infiltrating immune cells, comprising up to 50% of solid tumor [5, 6]

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