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SAM is required for methylation reactions including histone methylation and DNA methylation, in which it donates a methyl group and becomes S-adenosylhomocysteine (SAH)

10.1016/0166-2236(95)93946-U [DOI] [PubMed] [Google Scholar] Marchese A., Trejo J

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For research purposes, safety data are mainly relevant to dose-finding and study design in experimental models , not as endorsement of any clinical or self-administration use