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Validating these findings, we show that deletion of the mitochondrial pyruvate carrier, which is known to decrease TCA cycle activity and protect the liver from diet-induced injury, also diminished NADPH, elevated glutathione oxidation, and alleviated ER stress

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The same symptoms can come from very different biology: EPI is often managed with lifelong enzyme replacement, while PLE involves intestinal protein loss, swelling, and higher short-term mortality

A total of 42 participants (21 per group) completed the study

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