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To balance gene expression differences, one of the two X chromosomes in female cells undergoes X chromosome inactivation (XCI), a process that epigenetically silences most genes on the inactive X chromosome (Xi)
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compete with acetylcholine (ACh) for binding to postsynaptic nicotinic receptor sites SECONDARY MECHANISM: Nondepolarizing relaxants also from motor nerve endings by still poorly understood mechanism(s)
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It points to severe ulceration or medication-induced colitis
10.3389/fphar.2025.1545917 226
