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Biologicals 39, 242248

however, it produces glutathione-independent effects through the modulation of mitochondrial redox systems, ferroptosis, and the Nrf2-ARE signaling pathway

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GST enzyme requires glutathione in the detoxification process where harmful intermediate compounds are converted to water soluble molecules that can be easily excreted

This mechanism shares similarities with minoxidil, which is thought to act, at least in part, through VEGF-mediated vasodilation [98]