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Exosomes derived from mesenchymal stem cells(MSC-EXO) were found to regulate the AKT/ERK signaling pathway by delivering bioactive proteins, thereby inhibiting NRF2-mediated ferroptosis and improving the function and quantity of cells, which may serve as a novel drug carrier for islet-targeted therapy [90]

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Many unapproved peptides demonstrate favorable tissue repair and metabolic outcomes in animal models, but rigorous human safety data are scarce, and there is potential for serious harm to patients