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, 2015), which could regulate the binding affinity of APX1 for ascorbate, resulting in increased PRX activity

High ABCC1 expression was associated with poor disease-free survival 29 , and co-expression of multiple ABC transporters worsened the prognosis of AML patients 30

Further clinical studies are needed to define these issues

In HCC, lactate is no longer merely a metabolic byproduct

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doi: 10.3389/fphar.2025.1656316 Received 29 June 2025 Accepted 12 August 2025 Published 22 August 2025 Volume 16 - 2025 Edited by Barbara Ruaro, University of Trieste, Italy Reviewed by Mohammad Irshad Reza, North Dakota State University, United States Burak Okyar, Ministry of Health, Trkiye Jacopo Simonetti, Universit cattolica del Sacro Cuore di Roma, Italy Updates Copyright 2025 Zhang, Zhang, Hu and Zhang