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Additionally, total protein, albumin, and globulin levels may have some influence on MTXs clearance because of its about 50% protein binding rate (Mei et al
[DOI] [PMC free article] [PubMed] [Google Scholar] 41.MacKenzie S., Bergdahl A

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EPA and DHA can significantly downregulate the NF-B pathway, thereby lowering the expression of COX-2, TNF-, and other pro-inflammatory genes in tumors

revealed that target inhibition of PI3K or mTOR pathway might be a potential therapy (Martelli et al., 2011), and recently Banerjee et al

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