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Targeting Notch in oncology: the path forward

A study of the cerebral volume and induced stroke following middle cerebral artery occlusion in mice showed that HHcy was associated with increased oxidative damage and larger ischemic lesion [1719]

Necroptosis-related therapies are being explored in immune-oncology, as RIPK3 expression has been associated with better immune infiltration and outcomes in patients treated by immune checkpoint inhibitors, suggesting they are prognostic and therapeutic targets of necroptosis pathways (Thapa et al

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MPTP, 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine