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In wild-type cells, we observed a strong oxidation of the cytosolic NADP pool upon treatment with 2 and 5 mM diamide (Fig

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These extracts caused DNA nicks, apoptosis, and cell cycle arrest in a dose- and time-dependent manner by increasing the production of reactive oxygen species (ROS) and lowering mitochondrial potential [93] possibly by blocking the Protein Kinase C (PKC) [94]