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Theoretically, the use of pure -adrenergic receptor agonists, such as isoproterenol, and, to a lesser extent, dobutamine, is controversial as this may worsen hypotension mediated by 2-adrenergic receptor agonist-induced peripheral vasodilation

I., Wu, Y., Mishra, D., Donnelly, R

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Alcohol at higher intake levels is associated with liver disease, several cancers including colorectal and liver cancer, cardiovascular disease, high blood pressure, depression, cognitive decline, impaired sleep, reduced testosterone, and reduced fertility