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Their activity largely depends on sequence composition and the presence of hydrophobic, proline, lysine, or arginine residues, which influence structural stability and receptor affinity [262]

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Anti-cancer gene signatures: Some analyses suggest GHK-Cu upregulates genes associated with tumor suppression, including caspase and growth regulatory genes

As such, it was found to induce autophagy via inhibition of the mTor pathway, where beclin, ATG5 and LKB1 were upregulated and Akt, PRAS40 and 4E-BP1 were downregulated by decreasing its phosphorylation

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