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261 Lysosomal dysfunction is considered a critical factor in the development of many diseases, 261 which may manifest as impaired acidification, abnormal expression of lysosomal enzymes, lysosomal membrane stability issues, transport defects, and defects in autophagosome/endosome-lysosome fusion

or said antibody comprises a heavy chain variable region (VH) of an M25 AD antibody and a light chain variable region (VL) of an M25 AD antibody

Integrin inhibitor, Cilengitide TFA, Med Chem Express, Shanghai, China), the inhibitors were dissolved in culture medium containing DMSO at a final concentration not exceeding 0.1% for functional assessment

A., Tawfik, M

1 Introduction Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disorder that includes loss of tolerance to self-antigen and subsequent activation of autoreactive T and B cells, production of dysregulated cytokines ( The available treatment methods in SLE are chiefly immunosuppressants

Based on scientific evidence (Vyas and Erdman, 2009