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doi: 10.1016/0024-3205(88)90427-4 100 MagiakouMAMastorakosGGomezMTRoseSRChrousosGP

Despite demonstrating effective tumour suppression activity, most first- and second-generation CDK inhibitors failed to progress through clinical trials due to poor selectivity and severe dose-limiting toxicities [3]

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Mucus production and transport however is notoriously heterogeneous making it very hard to study with conventional lung function tests such as spirometry (eg FEV1)

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Ischemia-reperfusion (I/R) injury is linked to endoplasmic reticulum stress (ERS) and mitochondrial dysfunction, resulting in oxidative stress-induced acute kidney injury