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Whether the deposition of toxic metabolites in gut granules and the LRO-dependent elicitation of stress responses are separate or intertwined processes, as well as the extent of their contributions towards organismal protection, are open questions

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In the FSL rats, a combined treatment with sodium salicylate, which is a non-selective inhibitor of NF-B, counteracted the antidepressant effect of LAC on the expression of mGlu2 receptors, supporting the link between LAC-mediated mGlu2 induction and p65/NF-B [30]

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MTP: mitochondrial trifunctional protein Fatty oxidation disorders (FODs) are genetic defects in which body is unable to breakdown fatty acids to make energy