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Paradoxically, while iron toxicity in PD is linked to dysfunctional iron metabolism, intragastric delivery of iron carbonyl boosts the biosynthesis of iron-sulfur clusters and elevates aconitase 1 activity, which is crucial for mitochondrial function and iron homeostasis, thereby preventing ferroptosis in vivo (188)

The study product was discontinued, and the adverse event resolved without the use of concomitant medication

Additional findings suggest that the adaptogenic and anti-inflammatory effectiveness of Withania somnifera is strongly dependent on both the administered dose and the type of extract used

Biochem Pharmacol 62 : 787794 Rahman I, Yang SR, Biswas SK 2006 Current concepts of redox signaling in the lungs

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