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G, Zhang

Although alterations in genetic factors have been linked with its etiology, exponential accumulation of environmental entities such as reactive oxygen species (ROS) initiate a cyclic chain reaction resulting in accumulation of cellular inclusions, dysfunctional mitochondria, and overwhelming of antioxidant machinery, thus accelerating disease pathogenesis

This dilation permits white blood cells and blood plasma proteins to slip into the bloodstream and travel to the location of the injury or toxin, where immune system cells can begin to fight the invasion (Branco et al., 2018)

2016 Jan;157:84-104

[10] Some authors have broadened the definition of the Michael addition to essentially refer to any 1,4-addition reaction of ,-unsaturated carbonyl compounds