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Description
Impaired autophagy in humans, a catabolic process of cytoplasmic components, contributes to the aggregation and accumulation of -amyloid (A), cytoskeleton-related protein , and synuclein in neuronal cells and tissues 140
This might be due to the enhancement of T cell infiltration and increased lymphatic drainage, APC trafficking, and antigen transportation to TDLNs

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Jun 2021;87:54-58
therefore, for the accurate characterization of ferroptosis, metabolomic and lipidomic studies, which remain highly technically challenging, are needed 118,164,165,166,167
If serum calcitonin is measured and found to be elevated, the patient should be further evaluated