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None of the Epitalon-treated patients showed any exacerbation of their clinical condition [38]

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Other enzymes, such as AARS and alpha-tubulin ACT1 (ATAT1) have also been found to play a role

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1 - 13 There is a particular effect on endothelium integrity as well

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Tirzepatide Dual agonist : GLP-1 + GIP Central benchmark for dual incretin research Often discussed in relation to body-weight outcomes, glycaemic control and incretin signalling Single agonist : GLP-1 More selective and mechanistically narrower Common reference point for GLP-1 pathway research Triple agonist : GLP-1 + GIP + glucagon Broader receptor profile than Tirzepatide Often discussed in relation to weight loss, energy expenditure and next-generation multi-pathway metabolic modulation For researchers comparing incretin classes, Tirzepatide often functions as the middle reference point between single-pathway GLP-1 agonists and broader triple-agonist designs

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