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Collectively, these results indicate that -KG availability can be dictated by different metabolic enzymes depending on the cellular contexts, while -KG insufficiency broadly reduces AMPK expression and compromises energy sensing

In addition the IFN-inducible tripartite motif protein TRIM22 inhibits the budding of HIV-1 with diffuse cytoplasmic distribution of Gag rather than accumulation at the plasma membrane [145]

LiangYLiangBChenWet alPotential mechanism of dingji fumai decoction against atrial fibrillation based on network pharmacology, molecular docking, and experimental verification integration strategy

Proc Natl Acad Sci U S A 114:E3679E3688 [DOI] [PMC free article] [PubMed] [Google Scholar] 80.Fedoseyeva VB, Novosadova EV, Nenasheva VV, Novosadova LV, Grivennikov IA, Tarantul VZ (2023) Activation of embryonic gene transcription in neural precursor cells derived from the induced pluripotent stem cells of the patients with Parkinsons disease

Based on these facts and its presence in the liver, it is often associated with an animal origin

In the Action to Control Cardiovascular Risk in Diabetes-Memory in Diabetes (ACCORD-MIND) study, which included subjects with diabetes, microalbuminuria and elevated cystatin C levels were significantly correlated with poor performance in verbal memory and executive function, respectively