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In addition, cis -acting elements related to development were found in the promoter region of some Euphorbiaceae GST genes, such as circadian rhythm control element (Circadian), palisade mesophyll cell differentiation element (HD-Zip1), Zein metabolic regulatory element (O2-site), among others, indicating that these GST genes may be involved in regulation of growth and development of Euphorbiaceae plants (Supplementary Figures 14)

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Pathological myocardial hypertrophy not only impairs diastolic and systolic cardiac function but also predisposes individuals to severe complications such as arrhythmias and HF, presenting notable health risks (161)