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Furthermore, BTZ treatment in rats caused a decrease in SIRT1 levels, which subsequently reduced STAT3-mediated histone hyperacetylation in the neutrophilic alkaline phosphatase 1 promoter region of dorsal horn neurons, ultimately contributing to the development of mechanical pain hypersensitivity (Chen et al., 2018)

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[DOI] [PubMed] [Google Scholar] Jensen J

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