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Neuroinflammation following sleep deprivation has been studied as a pathogenic mechanism potentially mediating the association between sleep deprivation and neurodegenerative processes

These have more obvious safety and efficacy data.

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doi: 10.1006/taap.2002.9450

Yang C, Mo Y, Xu E, Wen H, Wei R, Li S, Zheng J, Li W, Le B, Chen Y, Pan H, Huang S, Wang S, Wang Q (2019) Astragaloside IV ameliorates motor deficits and dopaminergic neuron degeneration via inhibiting neuroinflammation and oxidative stress in a Parkinsons disease mouse model
