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[DOI] [PMC free article] [PubMed] [Google Scholar] 228.Xu K., Yu L., Wang Z., Lin P., Zhang N., Xing Y., Yang N

Abbreviations BaP Benzo(a)pyrene BCRP Breast Cancer Resistance Protein CSC Cancer Stem cells ECS Environmental Cigarette Smoke GPX Glutathione peroxidase GSH Glutathione GST Glutathione S-transferase HBEC Human Bronchial Epithelial Cells HBP 4-hydroxy-1-(3-pyridyl)-1-butanone ITC Isothiocyanate NAC N-acetyl cysteine NNK 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone PEITC Phenethylisothiocyanate Rb Retinoblastoma protein ROS Reactive oxygen species DDB2 DNA-damage binding protein 2 Footnotes Conflict of Interest Authors declare that there are no competing interests
& Bresalier, R

Thus, targeting the PPP for cancer therapy may be challenging (BOX2)