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doi: 10.3390/antibiotics11091238 83 LiangS
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An abundant naturally occurring serine protease inhibitor, 1-antitrypsin, was shown to prevent SARS-CoV-2 entry into host cells by inhibiting the protease activity of TMPRSS2, leaving the S2 domain uncleaved and therefore unable to undergo membrane fusion [88]
Published literature may describe its activity in cell-based and animal-model research, but those references are provided only for scientific context

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