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Swiss Med Wkly 147

These findings were supported by the relaxation of large vessels (ex vivo), mainly by acting on vascular endothelial cells but also on vascular smooth muscle cells, increasing NO production and migration of endothelial cells, activating the signal pathways of Src, Cav-1, and eNOS, and reducing proteinprotein interaction between eNOS and Cav-1 [121,122]

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Not only can the expression of these TJ proteins be influenced but also their localization within the cell can be dysregulated

Papaconstantinou, I

As in the case of the A 40 -fibrils with their U-shaped chains these results show that the presence of DRI-peptides has only little effect on a fully formed fibril, at least for the K28E mutant which similar to wild type L-A 42 -peptides can form a salt bridge between residues 28 and the C-terminus