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There are two main types of astrocytes in the SNC: Protoplasmic astrocytes, which envelope neuronal bodies and synapses and fibrous astrocytes which interact with the nodes of Ranvier and oligodendroglia [7]

In rats, long-term low-dose PS-NPs exposure reduced amygdalar metabolites-N-acetylserotonin, N-acetyl-L-tyrosine, and 4-aminobutyric acid, suggesting impaired neurotransmitter metabolism (Jiang et al., 2023)

The discovery of histone lactylation further reveals lactates capacity to directly reshape macrophage gene expression

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However, the use of different disease models leads to variations in research outcomes, posing a challenge for the translation of research on the relationship between ferroptosis and renal fibrosis into clinical applications
