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Description
When pooling five RCTs of vitamin D (from Iran, Europe, and Asia), we found a moderate overall effect (pooled SMD ~0.5 on symptom scales) favoring supplementation and a relative risk of ~1.6 for achieving a clinically significant improvement versus placebo

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US Patent 2023/0141224, 11 May 2023

[Google Scholar] 50.Pihan G., Majzoubi D., Haudenschild C., Trier J.S., Szabo S

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It is a non-hormonal approach: no IGF-1 or cortisol changes, no stimulant jitters, no appetite suppression
