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Bates CJ, Schneede J, Mishra G, et al

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What they found: In normal obese mice: AOD-9604 reduced body fat by 21 % vs placebo, hGH by 24 % The AOD-9604 effect was fully dependent on the 3-adrenergic receptor , in knock-out mice no effect The hGH effect was partly independent of 3-AR , in knock-out mice there was still ~10 % fat reduction AOD-9604 did not raise IGF-1 (control level), whereas hGH raised IGF-1 by 80 % No changes in growth, organ weights (except adipose tissue), fasting insulin Why it matters: The study provided the mechanistic basis for AOD-9604 and confirmed the key business hypothesis: it is possible to separate the lipolytic effect of GH from its growth effect

What exists is largely preclinical, but preclinical evidence isnt no evidence, he added in an interview via email

Additionally, the concentration of AOD9604 in the synovial fluid after injection was estimated to be about 0.19 mg/mL, similar to concentrations used in previous GH injection studies in animal models