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87 demonstrated that inhibition of the histone H3K4 methylation complex (composed of ASH-2, WDR-5 and SET-2) and overexpression of RBR-2, the enzyme that mediates H3K4 demethylation, resulted in lifespan extension

Previous clinical studies have examined effects of polyphenol-rich interventions on fasting trimethylamine N-oxide (TMAO) concentrations but have not assessed pharmacokinetic TMAO responses following an oral carnitine challenge (OCC)

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