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247 Increased fat mass, metabolic dysfunction, and systemic inflammatory responses are key features of these metabolic diseases and can further exacerbate immune dysfunction associated with aging

239 Mitochondrial iron accumulation lead by Fe-S cluster deficiency can further induce iron-mediated ROS increasing and subsequent ferroptosis that due to lipid peroxides accumulation

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Vitamin E supplementation and in vivo immune response in healthy elderly subjects
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Our previous study has indicated that ROS-mediated mitochondrial dysfunctions are observed in DMM-induced OA mice [46]
