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Dapagliflozin treatment maintains muscle stem cell number and quiescence To assess whether early treatment of hyperglycemia rescued MuSC dysfunction, we administered the glucose-lowering drug, dapagliflozin (dapa, 25 mg/kg/day), or vehicle (veh, dimethyl sulfoxide, DMSO), in the drinking water of WT and Akita mice

Gut mucosal barrier Treatments that restore the gut barrier and prevent bacterial translocation have the potential to remove underlying causes of infection, inflammation, and immune activation in critical illness [308]

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10.1111/and.13387 84
Molecular and clinical heterogeneity in pyruvate kinase deficiency in India

By simultaneously eliminating senescent cells and modulating the harmful effects of their secretory phenotype, combination therapies hold the potential to address the multifaceted nature of aging and age-related diseases.39,119 This integrated approach offers a comprehensive strategy for improving healthspan, reducing chronic inflammation, and enhancing tissue regeneration
