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If a clinical trial is not suitable: Your healthcare provider may consider whether an early access program may be appropriate Your healthcare provider submits a request on your behalf Your request is reviewed for safety, ethics, and eligibility by the sponsor and/or regulatory authority If approved, you receive the treatment Your healthcare provider will monitor your health and report any safety concerns

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Another DPP1 inhibitor, BI 1291583, showed generally positive results and an acceptable safety profile in phase 1 studies in healthy volunteers, supporting the initiation of a phase 2 trial in patients with bronchiectasis (Airleaf

[DOI] [PubMed] [Google Scholar] 157.Clayburgh DR, et al

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Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes