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These evidence, while observed in cardiomyocytes and vascular smooth muscle cell metabolism, is also applicable to explain other important system functional imbalance in the lipotoxic state of high FFAs

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Hepatology 1996

Some studies suggest vitamin B12 deficiency may contribute to cognitive decline and memory impairment

Therefore, to address whether p53 is involved in controlling the cellular tolerance to FA, we inactivated the gene coding for this factor ( TP53 ) and the one coding for ADH5 in HCT116 cells (Supplementary Fig