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Integrin signaling through elevated integrin 1 and 1 expression mediates cell adhesion to extracellular matrix, cell migration and proliferation, growth factor secretion, and cytoskeleton organization

However, they found that in knock-in mice expressing MOR mutant S375A substitution, proposed by these authors to be the primary site of morphine-induced phosphorylation of MOR responsible for desensitization (Schulz et al., 2004), morphine tolerance was not affected (Grecksch et al., 1999) cannot be extended to DOR