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A strict vegetarian diet may lead to deficiency of LC since red meat is the richest source of lysine

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Ferroptosis: past, present and future

One of the proposed mechanisms for the onset of hand-foot syndrome induced by traditional chemotherapy drugs is excretion of the chemotherapy agents via the sweat glands.11 This mechanism could not however be demonstrated for hand-foot skin reaction associated with multikinase inhibitors, as significant levels of sorafenib were not detected in the sweat of these patients.19 In this case, the authors proposed leakage of the drug through capillaries damaged by subclinical trauma as the pathogenic mechanism