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Over time, elevated cortisol levels can lead to skin dullness, sagging and fine lines

J Autism Dev Disord 45:16891698

GDH1-derived AKG directly engages and activates the IKK-NF-B signaling axis, thereby upregulating the expression of the glucose transporter 1 (GLUT1) to promote compensatory glucose uptake and tumor cell survival under low glucose conditions [133]
Morrissey J, Mellnick V, Luo J, Siegel M, Figenshau R, Bhayani S, et al

Important note: Brightening or tone-evening is different than whitening (which implies changing your natural skin shade)

doi: 10.17219/pim/189406 58 HungCMTsaiTHLeeKTHsuYC